当研究室のメンバーがこれまでに発表した論文
当研究室のメンバー、論文発表当時中田研究室に所属していたメンバーに下線。
当研究の研究員が以前に所属していた研究室での成果も載せています。（＊Corresponding Author(s) # Equal Contribution）
- Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, Ogi T, Nakada S＊
Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells.
Nat Commun 14, Article number: 5607, 2023 - Katsuki Y, Abe M, Park SY, Wu W, Yabe H, Yabe M, van Attikum H, Nakada S, Ohta T, Seidman MM, Kim Y, Takata M.
RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.
Cell Rep. 37 109879-109879,2021 - Oka Y, Hamada M, Nakazawa Y, Muramatsu H, Okuno Y, Higasa K, Shimada M,
Takeshima H, Hanada K, Hirano T, Kawakita T, Sakaguchi H, Ichimura T, Ozono
S, Yuge K, Watanabe Y, Kotani Y, Yamane M, Kasugai Y, Tanaka M, Suganami
T, Nakada S, Mitsutake N, Hara Y, Kato K, Mizuno S, Miyake N, Kawai Y, Tokunaga K,
Nagasaki M, Kito S, Isoyama K, Onodera M, Kaneko H, Matsumoto N, Matsuda
F, Matsuo K, Takahashi Y, Mashimo T, Kojima S, Ogi T.
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Sci Adv. 6, eabd7197, 2020 - Akagawa R, Trinh HT, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki
MT, Nakada S, Takeda S, Sasanuma H.
UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks.
iScience 23 101027-101027, 2020 - Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y,
Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi
Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T.
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Cell 180 1228-1244, 2020 - Morisaka H, Yoshimi K, Okuzaki Y, Gee P, Kunihiro Y, Sonpho E, Xu H, Sasakawa
N, Naito Y, Nakada S, Yamamoto T, S ano S, Hotta A, Takeda J, Mashimo T.
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells.
Nat Commun 10 5302, 2019 - Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike
H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S.
BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes.
Proc Natl Acad Sci U S A. 115 E10642-E10651, 2018 - Yasuhara T, Kato R, Hagiwara Y, Shiotani B, Yamauchi M, Nakada S, Shibata A, Miyagawa K
Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.
Cell 175 558-570.e11, 2018, - Nakajima K#1, Zhou Y#1,Tomita A#2,Hirade Y#2, Gurumurthy CB, Nakada S*
Precise and Efficient Nucleotide Substitution near Genomic Nick via Non-Canonical Homology-Directed Repair
Genome Res. 2018. 28: 223-230. doi:10.1101/gr.226027.117 - Takahashi TS, Hirade Y, Toma A, Sato Y, Yamagata A, Goto-Ito S, Tomita A, Nakada S*. Fukai S*.
Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
Nat Commun. 2018 Jan 12;9(1):170. doi: 10.1038/s41467-017-02345-y. - Nibe Y, Oshima S, Kobayashi M, Maeyashiki C, Matsuzawa Y, Otsubo K, Matsuda
H, Aonuma E, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Nakada S, Watanabe M.
Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.
Autophagy. 2017 Nov 22:1-43. doi: 10.1080/15548627.2017.1407889. [Epub ahead of print] - Inano S, Sato K, Katsuki Y, Kobayashi W, Tanaka H, Nakajima K, Nakada S, Miyoshi H, Knies K, Takaori-Kondo A, Schindler D, Ishiai M, Kurumizaka
H, Takata M*
The E3 ligase RFWD3 promotes timely removal of both RPA and RAD51 from DNA damage sites to facilitate homologous recombination
Mol Cell. 2017 Jun 1;66(5):622-634.e8. doi: 10.1016/j.molcel.2017.04.022. - Isono M, Niimi A, Oike T, Hagiwara Y, Sato H, Sekine R, Yoshida Y, Isobe
S, Obuse C, Nishi R, Petricci E, Nakada S, Nakano T, Shibata A*
BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation
Cell Rep. 2017 Jan 10;18(2):520-532. doi: 10.1016/j.celrep.2016.12.042. - Nakada S*
Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice
J Radiat Res. 2016 Aug;57 Suppl 1:i33-i40. doi: 10.1093/jrr/rrw027. Epub 2016 Mar 16. - Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K*.
Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining
Oncogene. 2015 Aug 13;34(33):4403-11. doi: 10.1038/onc.2014.371. Epub 2014 Nov 24 - Hirade Y, Kotoku N, Terasaka K, Saijo-Hamano Y, Fukumoto A, Mizukami H.
Identification and functional analysis of 2-hydroxyflavanone C-glucosyltransferase in soybean (Glycine max)
FEBS Lett. 2015 Jul 8;589(15):1778-86. doi: 10.1016/j.febslet.2015.05.010. - Toma A, Takahashi TS, Sato Y, Yamagata A, Goto-Ito S, Nakada S, Fukuto A, Horikoshi Y, Tashiro S, Fukai S*.
Structural basis for ubiquitin recognition by ubiquitin-binding zinc finger of FAAP20
PLoS One. 2015 Mar 23;10(3):e0120887. doi: 10.1371/journal.pone.0120887. eCollection 2015. - Kato K#, Nakajima K#, Ui A, Muto-Terao Y, Ogiwara H, Nakada S*
Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice
Mol Cell. 2014 Feb 20;53(4):617-30. doi: 10.1016/j.molcel.2014.01.030. - Nakada S*, Yonamine RM, Matsuo K.
RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1
Cancer Res. 2012 Oct 1;72(19):4974-83. doi: 10.1158/0008-5472.CAN-12-1057. Epub 2012 Aug 3. - Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S*, Fukai S*
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13
J Biol Chem. 2012 Jul 27;287(31):25860-8. doi: 10.1074/jbc.M112.364752. Epub 2012 Jun 7. - Nakada S*
Abnormalities in DNA double-strand break response beyond primary immunodeficiency
Int J Hematol. 2011 Apr;93(4):425-33. doi: 10.1007/s12185-011-0836-5. Epub 2011 Apr 12. - Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
Blood. 2011 Apr 21;117(16):4169-80. doi: 10.1182/blood-2010-08-297390. Epub 2011 Feb 4. - Nakada S*, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro
M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D*
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
Nature. 2010 Aug 19;466(7309):941-6. doi: 10.1038/nature09297. - Hishida T, Hirade Y, Haruta N, Kubota Y, Iwasaki H.
Srs2 plays a critical role in reversible G2 arrest upon chronic and low doses of UV irradiation via two distinct homologous recombination-dependent mechanisms in postreplication repair-deficient cells
Mol Cell Biol. 2010 Oct;30(20):4840-50. doi: 10.1128/MCB.00453-10. Epub 2010 Aug 16. - Stewart GS*, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro
A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM,
Durocher D*
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
Cell. 2009 Feb 6;136(3):420-34. doi: 10.1016/j.cell.2008.12.042. - Nakada S, Chen GI, Gingras AC, Durocher D*
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint
EMBO Rep. 2008 Oct;9(10):1019-26. doi: 10.1038/embor.2008.162. Epub 2008 Aug 29. - Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, Mizutani S
Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes
Cancer Sci. 2008 Aug;99(8):1539-45. doi: 10.1111/j.1349-7006.2008.00862.x. - Kolas NK#, Chapman JR#, Nakada S#, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson
TM, Pelletier L, Jackson SP, Durocher D.
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
Science. 2007 Dec 7;318(5856):1637-40. Epub 2007 Nov 15. - Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D.
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions
PLoS Genet. 2007 Aug;3(8):e134. - Nakada S, Katsuki Y, Imoto I, Yokoyama T, Nagasawa M, Inazawa J, Mizutani S*
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
J Clin Invest. 2006 Jan;116(1):80-9. Epub 2005 Dec 15. - Chen L, Morio T, Minegishi Y, Nakada S, Nagasawa M, Komatsu K, Chessa L, Villa A, Lecis D, Delia D, Mizutani
S.
Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage
Cancer Sci. 2005 Feb;96(2):134-41. - Takagi M, Tsuchida R, Oguchi K, Shigeta T, Nakada S, Shimizu K, Ohki M, Delia D, Chessa L, Taya Y, Nakanishi M, Tsunematsu
Y, Bessho F, Isoyama K, Hayashi Y, Kudo K, Okamura J, Mizutani S*
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease
Blood. 2004 Jan 1;103(1):283-90. Epub 2003 Sep 11. -